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Dimitar Stavrev Prodromov

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#diffusion models Open access Sep 2026

AETERNA SELYE ENGINE: A Deterministic Physiological Digital Twin of the Neuroendocrine HPA-Axis, Mitochondrial Allostatic Load, and Epigenetic Aging Dynamics

AETERNA SELYE ENGINE (v1.0.0-SINGULARITY) establishes the first mathematically closed, deterministic and stochastic physiological digital twin of the human neuroendocrine Hypothalamic-Pituitary-Adrenal (HPA) axis and Hans Selye's tripartite General Adaptation Syndrome (Alarm, Resistance, Exhaustion). Coupling continuou...

Dimitar Stavrev Prodromov · 0 citations

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