Sep 2026
Single-cell transcriptomics and multi-omics integration identify necroptosis-driven core targets and tubular-immune crosstalk in chronic kidney disease.
BACKGROUND Current pharmacotherapies for chronic kidney disease (CKD) are limited by adverse effects and a "one-target-one-drug" paradigm. Necroptosis is a key driver of renal deterioration, yet its regulatory network remains poorly defined. Modified Da-Huang-Fu-Zi Decoction (DHFZ) has shown clinical efficacy, although...
Si-Teng Zhang, Wei Zhu, Guo-Fang Huang et al.
· Computational biology and ch... · 0 citations