Author

Ding-Jie Xu

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Open access Sep 2026

Nobiletin ameliorates diabetic nephropathy by modulating TP53-associated PANoptosis: an experimental study

Background Nobiletin (NOB), a naturally occurring polymethoxyflavone enriched in Citri Reticulatae Pericarpium—the dried peel of mature citrus fruit—has attracted increasing attention because of its multi-target pharmacological activities. This study explored the protective effects of NOB on diabetic nephropathy (DN),...

Bi-Wei Zhang, Yi Liu, Lei-Lei Ma et al. · Frontiers in Nutrition · 0 citations

Open access Aug 2026

Systematic evaluation of spatial transcriptomic annotation methods reveals conserved tumor microenvironment programs in NSCLC

Introduction Spatial transcriptomics (ST) enables high-resolution mapping of cellular heterogeneity in tumor microenvironments, but downstream cell-type annotation remains highly method-dependent. Methods Here, we systematically evaluated four representative annotation frameworks—Seurat, CARD, RCTD, and SPOTlight—acros...

Mingke Wu, Yi Ting Zhou, Ding-Jie Xu · Frontiers in Bioinformatics · 0 citations