CCL2/CCR2 axis suggests a role in bridging obesity-related adipose inflammation to Sertoli cell injury in asthenozoospermia: Integrated multi-omics, machine learning and in vitro validation.
This study established an integrated framework combining multi-omics analysis, machine learning (ML), single-cell RNA sequencing (scRNA-seq), molecular docking, and in vitro validation to investigate potential mechanisms and therapeutic targets of obesity-associated asthenozoospermia (AZS). Based on transcriptomic data...