Dingyan Lu

CYP2C19-Mediated Metabolic Activation and OAT3/P-gp-Associated Transport Contribute to Dioscorea bulbifera L.-Induced Hepatotoxicity.

ETHNOPHARMACOLOGICAL RELEVANCE Dioscorea bulbifera L. (DBL) is a traditional medicinal herb, but its clinical use is often limited by its potential to cause herb-induced liver injury. 8-Epidiosbulbin E acetate (EEA) is recognized as the major hepatotoxic constituent in DBL; however, the mechanisms underlying the drug t...