Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder predominantly affecting 47 million people worldwide. Dysregulation of BACE-1, the initiating enzyme in the amyloidogenic cascade, plays a pivotal role in AD pathogenesis. Conventional anticholinesterase inhibitors can only provide symptomat...
Pitam Ghosh, Ryena Dhir, Dinki Sharma et al.· Journal of Computational Bio...· 0 citations
This review focuses on the AI-based approaches for target discovery, virtual screening, molecular generation, lead optimization, retro-synthesis, and structural modeling while also addressing issues of dataset bias, reproducibility, and real-world applicability.