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Dipendu Das

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Oct 2026

Discovery of Pyrazolopyrimidines as Potent and Orally Bioavailable MRGPRX2 Antagonists

The Mas-related G protein-coupled receptor X2 (MRGPRX2) mediates IgE-independent mast cell activation and is implicated in pseudoallergic drug reactions, chronic urticaria, atopic dermatitis, rosacea, neurogenic inflammation, and other mast cell-mediated disorders. Herein, we report the discovery of a pyrazolopyrimid...

Minh-Hai Nguyen, Hai-Fen Ye, Heeoon Han et al. · 0 citations

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