Open access
Jul 2026
PRISM : Peptide-specificity annotation of T-cell receptors with uncertainty quantification
PRISM embeds receptors into a peptide-organized latent space, returns top-k peptides by nearest-neighbor retrieval, and abstains on out-of-distribution receptors by modeling an intrinsic uncertainty that tracks annotation correctness.
Divya Lakshmi Venkatraman, Lydia Mok, N. Rose et al.
· bioRxiv · 0 citations