Preclinical mechanistic study of rotundic acid against cyclophosphamide-induced nephrotoxicity in Swiss albino mice through modulation of oxidative stress, inflammation, apoptosis, and fibrosis via NF-κB/Caspase-3/TGF-β1 Pathways.
RA may effectively mitigate CP-induced nephrotoxicity and could be considered a potential adjuvant to CP in cancer therapy, however, further studies using appropriate cancer models are essential to confirm and validate its therapeutic potential.