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Author

Dmitry Zamarin

2 papers indexed here

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Open access Nov 2026

An information-theoretic framework for inferring T cell dynamics from single-cell RNA and T cell receptor sequencing.

Single-cell T cell receptor (TCR) repertoire sequencing enables simultaneous profiling of gene expression and TCR sequences, providing a coregistered measure of T cell phenotypic diversity and clonal dynamics. However, principled probabilistic frameworks for joint modeling of clonotype and phenotype have remained limit...

N. Ceglia, Sohrab Salehi, Z. Sethna et al. · 0 citations
Open access Aug 2026

Safety and efficacy of intratumoral MEDI1191, an IL-12 mRNA lipid nanoparticle, plus intravenous durvalumab in patients with advanced solid tumors: a first-in-human study.

D dose-escalation results from a first-in-human, open-label, phase I study of intratumoral MEDI1191 plus intravenous durvalumab were tolerated and preliminary antitumor activity was encouraging in these heavily pretreated patients, including patients previously treated with immune checkpoint inhibitors.

B. Carneiro, Thomas U. Marron, Dmitry Zamarin et al. · 0 citations

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