Author

Do-Gyeong Kim

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Open access Sep 2026

Lapatinib suppresses cysteine deprivation-induced ferroptotic cell death by modulating mitochondrial function

Ferroptosis, an iron-dependent regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic target for cancer. Although lapatinib has been reported to induce ferroptosis in several cancer types, we found that it exerts a ferroptosis-suppressive effect under cysteine deprivation. Lapatinib a...

Gyeongmi Kim, S. Jang, Do-Gyeong Kim et al. · Medical Oncology · 0 citations

Open access Sep 2026

Tubacin induces TFEB-dependent ferritinophagy independently of HDAC6 and sensitizes cancer cells to ferroptosis under GSH-GPX4 axis disruption.

Histone deacetylase 6 (HDAC6) is a promising therapeutic target in cancer. However, its inhibitors show limited efficacy as monotherapies and are more effective in combination settings, suggesting a context-dependent mechanism that remains poorly defined. Here, we show that tubacin sensitizes cancer cells to ferroptosi...

Gyeongmi Kim, S. Jang, Do-Gyeong Kim et al. · Biochemical Pharmacology · 0 citations