Review
Open access
Aug 2026
Programmed cell death-1: from a T-cell immune checkpoint to a regulator of Natural Killer cell biology
The molecular mechanisms governing PD-1 expression and signaling, its contribution to immune dysfunction in cancer and chronic diseases, and the potential implications of targeting the PD-1 axis to enhance both adaptive and innate antitumor immunity are discussed.
Fabiana De Franco, Marco Greppi, Valentina Obino et al.
· Frontiers in Cell and Develo... · 0 citations