Dong-Bo Wu

Tuberculosis-Associated Hemophagocytic Lymphohistiocytosis with Bone Marrow Involvement: Case Report and Literature Review

Tuberculosis is a rare but fatal trigger of secondary hemophagocytic lymphohistiocytosis (HLH). Its diagnosis is challenging because clinical manifestations overlap with HLH, and immunological tests may be falsely negative in HLH-related immune dysfunction. We report a case of a 34-year-old male with fever and pancytop...

The ATG4 family: Molecular gatekeepers of autophagic flux and emerging targets for disease intervention.

Autophagy represents an evolutionarily conserved intracellular degradation pathway. Aberrant activation or impaired autophagic flux contributes substantially to the pathogenesis and progression of numerous human diseases, such as tumors and neurological disorders. As the only cysteine proteases within the core autophag...

Label-Free Urinary Proteomics Uncovers Immune-Related Non-Invasive Biomarkers for Primary Biliary Cholangitis

Diagnosis of primary biliary cholangitis (PBC) currently depends on invasive liver biopsy or serum markers with inadequate diagnostic performance. This study aimed to identify non-invasive urinary protein biomarkers for PBC detection. Urine specimens from biopsy-verified PBC patients and healthy controls were processed...

Drugging small-molecule compounds in autophagy-dependent cell death to overcome cancer therapy resistance