Two separate homeostatic-to-activated and activated-to-homeostatic trajectories suggest that transplantation-induced host myeloid activation is dynamic and partially reversible, with implications for improving future retinal cell therapies.
Emil Kriukov, A. Mukwaya, Paul F. Cullen et al.· iScience· 0 citations
Microglia are the resident immune cells of the central nervous system, responsible for defending against infections, responding to tissue damage, and maintaining homeostasis. Dysregulation of their phagocytic activity has been implicated in many neurodegenerative diseases of the brain and the eye, including Alzheimer's...
A. Mukwaya, Zhuoran Yin, Ryan Yarcusko et al.· Frontiers in Neuroscience· 0 citations
Current knowledge of this integrated regulatory network, encompassing signaling pathways including Notch, Wnt/β-catenin, MAPK/ERK, PI3K/AKT, SMADs, and Hippo-YAP, alongside key transcription factors and epigenetic mechanisms, that collectively govern MG cell cycle reentry and neurogenesis in mammals are synthesized.
Lu Huang, Ethan Yao, Menglu Yang et al.· American Journal of Patholog...· 1 citation
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