Dong-Dong Wang

The role and mechanism of CHST6-mediated lactation modification in lenvatinib resistance in hepatocellular carcinoma cells.

BACKGROUND Hepatocellular carcinoma (HCC) is the 3rd leading cause of cancer-related death. Approximately 70% of HCC patients present with advanced-stage disease at the time of diagnosis. Lenvatinib is a standard first-line treatment for HCC; however, the development of drug resistance substantially limits its therapeu...