Author

Dong-Dong Zhao

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Review Open access Sep 2026

Breaking the deadlock of metallo-β-lactamases: evidence and prospects for Aztreonam/Avibactam

ABSTRACT Multidrug-resistant Gram-negative bacteria pose a significant threat to global public health, with resistance mediated by metallo-β-lactamases being particularly prominent. Aztreonam/avibactam (AZA), a novel β-lactam/β-lactamase inhibitor combination, had been approved in China and the European Union for treat...

Jun-Xin Zhou, Rui Weng, Yi-Ning Ye et al. · Emerging Microbes and Infect... · 0 citations

Open access Aug 2026

Host-dependent effects of mcr-1 and mcr-8 on fitness, virulence, and transmission in Escherichia coli and Klebsiella pneumoniae

Introduction As one of the most common groups of clinical pathogens, Enterobacterales pose a serious threat to global public health due to their multidrug-resistance. Polymyxin serves as a last-line treatment for infections caused by Carbapenem-resistant Enterobacterales (CRE). The emergence and spread of the mobilized...

Meng-Yu Zhou, Yi-Ning Ye, Nuo-You Cheng et al. · Frontiers in Microbiology · 0 citations