Chronic Obstructive Pulmonary Disease (COPD) remains a leading cause of global morbidity and mortality, characterized by progressive airflow limitation and chronic inflammation that current therapies fail to effectively modify. The recent discovery of cuproptosis-a copper-dependent, regulated cell death mechanism drive...
Feng-Xian Ni, Jie Hu, Pei-sheng Chen et al.· International Immunopharmaco...· 0 citations
Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome characterized by persistent oxidative stress and maladaptive immune responses, rather than a single disease entity. Oxidative stress not only damages lung tissue but also reprograms immune cells through both classical epigenetic mechanisms (DNA me...
Chun-Feng Pan, Qiong Wan, Feng-Xian Ni et al.· Frontiers in Immunology· 0 citations
Ferroptosis, a regulated cell death pathway driven by iron-dependent lipid peroxidation, has emerged as a promising strategy for cancer therapy. Nevertheless, the direct delivery of iron can lead to systemic toxicity. In this study, a nonferrous ferroptosis-like strategy employing 2D Ti3C2 MXene nanosheets was develope...
The bidirectional metabolism-m6A crosstalk as a theoretical framework requiring experimental validation, and single-cell m6A sequencing, spatial metabolomics, and CRISPR screening as tools to accelerate precision TCM for COPD are outlined.
Hui-Hui Chen, Feng-Xian Ni, Dong-Hui Huang et al.· Frontiers in Immunology· 0 citations
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