Review
Open access
Aug 2026
Alpha-ketoglutarate alleviates chronic kidney disease via mitochondrial protection, gut microbiota, and metabolite remodeling.
Chronic kidney disease (CKD) is a significant global health challenge, yet no effective pharmacological interventions exist for it. Alpha-ketoglutarate (AKG) is widely utilized in food and nutritional supplements, demonstrating anti-inflammatory, antioxidant, and gut barrier-protective properties. However, the therapeu...
Juan Xie, Hailun Li, Haijing Dou et al.
· Journal of Pharmaceutical an... · 0 citations