Dong-Jin Zhan

Genomic RNA and DNA next generation sequencing (mNGS) for the diagnosis of neonatal sepsis---based on host and pathogen plasma genomics detection

Background Neonatal sepsis is difficult to confirm because clinical signs are nonspecific and blood culture is slow and insensitive. Metagenomic next-generation sequencing (mNGS) of plasma can detect pathogen nucleic acids without culture, while plasma RNA may capture the host response. Whether combined DNA and RNA pla...