Sep 2026
LASS2 alleviates liver fibrosis by interacting with THBS1, TFRC, and APOE to inhibit TGF-β1 signaling and ferroptosis, and by reshaping the hepatocyte lipid secretome to suppress paracrine HSC activation.
BACKGROUND Liver fibrosis (LF) lacks effective therapies. Longevity assurance homolog 2 (LASS2), a key ceramide synthase, contributes to liver homeostasis, but its role in LF remain unclear. METHODS Bioinformatics revealed LASS2 correlation with classic fibrotic factors, and its expression was assessed in fibrotic mo...
Rong-Jin Yu, Xiao-Yu Li, Yun-Fei Huang et al.
· Cellular Signalling · 0 citations