Background Sensory hair cells (HCs) rely on a highly polarized apical apparatus, composed of actin-rich stereocilia and a microtubule-based kinocilium, to detect mechanical stimuli. Although tektins are conserved microtubule-associated proteins enriched in cilia and flagella, their roles in sensory HC morphogenesis and...
Biao Li, Po Xue, Jie Sun et al.· Frontiers in Cell and Develo...· 0 citations
INPP5D, which encodes Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1), has emerged as an Alzheimer’s disease (AD)-associated gene with strong links to microglial biology. As a hematopoietic-enriched lipid phosphatase, SHIP1 converts phosphatidylinositol-3,4,5-trisphosphate to phosphatidylinositol-3,4-...
Jun-Xiang Xu, Yi-Jin Chang, Dong Liu et al.· Neurology International· 0 citations
Sensory hair cells (HCs) are susceptible to damage, typically causing permanent hearing and balance deficits in mammals due to limited regeneration. Understanding spontaneous regeneration in non-mammalian models offers key insights for restoring sensory function. Here, we establish a zebrafish semicircular canal crista...
Jie Gong, Chao Yang, Gui-Yi Zhang et al.· Nature Communications· 0 citations
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