Open access
Aug 2026
Targeting the HIF-1α/IL-1β Axis in Macrophages With the Novel Inhibitor LJ-6 Mitigates Adipose Tissue Inflammation in Cellular and Ex Vivo Models.
BACKGROUND Sustained activation of adipose tissue macrophages (ATMs) drives metabolic dysfunction in obesity, with the hypoxia-inducible factor-1α (HIF-1α)/interleukin-1β (IL-1β) axis being a core signaling pathway. However, specific strategies targeting this axis are still lacking. Here, we aimed to identify novel com...
Min Gao, Meng-Yuan Liu, An-Ran Chu et al.
· Frontiers in Bioscience · 0 citations