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Dong-Sheng Zhang

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Review Open access Sep 2026

Engineering TnpB as a compact RNA-guided genome editor from molecular constraints to design principles

Recent discoveries of non-CRISPR RNA-guided nucleases have expanded the landscape of programmable genome editing beyond canonical Cas systems. Among these, TnpB proteins derived from IS200/IS605-family transposable elements are ultra-compact RNA-guided DNA endonucleases with potential for delivery-constrained genome en...

Bin Ma, Yi-Miao Li, Dong-Sheng Zhang et al. · 0 citations

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