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Open access Aug 2026

Activation of the Nrf2-ARE Signaling Pathway Mediates the Neuroprotective Effects of Exercise in a Mouse Model of Chronic Parkinson’s Disease

Clear pharmacological evidence is provided that the neuroprotective effect of regular treadmill exercise against chronic PD strictly depends on the Nrf2-ARE pathway, indicating that Nrf2 is a key mechanistic node linking exercise and neuroprotection.

Shu-Wei Zhang, Dong Yang, Chang-Fa Tang et al. · 0 citations

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