Integrated bioinformatics and experimental validation reveal that kaempferol ameliorates intervertebral disc degeneration via dual anti-inflammatory and anti-aging pathways.
This study systematically analyzed the molecular mechanism by which kaempferol improves IVDD through multi-target regulation by integrating bioinformatics analysis, animal experiments, and cell models, and reveals for the first time that kaempferol upregulates core gene networks such as AURKB and CCNB1 while suppressin...