Open access
Aug 2026
Liver cells-derived extracellular vesicles deliver a dual-functional RNA ligand for TACE treatment of hepatocellular carcinoma.
This work developed a 5' triphosphorylated oligonucleotide (imm-miR223) with dual function as miR-223 analogue and RIG-I activation, and delivered this RNA molecule to HCC cells efficiently using normal hepatic cell-derived extracellular vesicles (EVs).
Huayuan Xiang, Jianhao Zhang, Qing Gao et al.
· Biochemical Pharmacology · 0 citations