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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Dongwoo Kim

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Open access Aug 2026

A Pyrazole-Based Small Molecule, KB3409, Restores Mitochondrial Function via VCP Activation and RCN2-Dependent Ca2+ Regulation

Cellular senescence is characterized by the accumulation of reactive oxygen species (ROS), and the selective elimination of excessive ROS remains a key therapeutic challenge. Through antioxidant screening, we identified the pyrazole-based small molecule KB3409 as a potent regulator that reduces ROS levels in senescent...

Yoo Jin Lee, Jee hee Yoon, Hyunwoong Lim et al. · 0 citations

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