Open access
Jul 2026
CENO: A Genome-Scale World Model for Evolutionary Sequence Interpretation and Programmable Regulatory Design
CENO is introduced, a family of long-context generative genomic world models designed to preserve local DNA grammar while extending usable context to regulatory and chromatin scales and provides a genome-scale sequence world-model framework for sequence interpretation, evolutionary reasoning, gene-scale reconstruction and programmable regulatory sequence generation.
Mingqian Ma, Yucheng Wu, Xin Chen et al.
· bioRxiv · 0 citations