Open access
Aug 2026
Astrocytic Caveolin-1 drives white matter injury via aberrant cathepsin D trafficking in vascular cognitive impairment
Efficient clearance of myelin debris is essential for white matter repair in vascular cognitive impairment (VCI) caused by chronic cerebral hypoperfusion, but the underlying cell-specific mechanisms remain poorly defined. Here, we investigated the role of astrocytic Caveolin-1 (Cav-1) in regulating this process....
Min Wu, Mingming Zha, Ying Zhao et al.
· Journal of Neuroinflammation · 0 citations