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Donia E. Hafez

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Oct 2026

Oxcarbazepine-loaded nanoemulsions in thermosensitive nasal gels for epilepsy: in-vitro and in-vivo evaluation in status epilepticus rat model.

To overcome the low aqueous solubility of oxcarbazepine (OXC), a BCS Class II drug, and to enhance brain exposure following intranasal administration, OXC was formulated into a self-nanoemulsifying drug delivery system (SNEDDS) incorporated within a thermosensitive nasal gel. The optimized SNEDDS (SNE.O2), comprising r...

Mina S. Mikhail, Reham M. Essam, Mohamed Salah et al. · 0 citations

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