Author

Dorota Nowak

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Open access Sep 2026

PFKFB3 and PFKFB4 inhibition modulates the response of metabolically plastic resistant melanoma cells to BRAF/MEK-targeted therapy

Despite the development of selective inhibitors targeting oncogenic BRAF mutations, melanoma therapy remains limited by acquired resistance driven by multiple mechanisms, including metabolic reprogramming. PFKFB isoenzymes regulate cellular adaptation to therapeutic stress and may therefore represent promising th...

S. Trojan, B. Ostrowska, P. Kaczara et al. · Cell Communication and Signa... · 0 citations

Open access Aug 2026

Metabolism alterations accompany the invasive phenotype of melanoma cells resistant to BRAF/MEK inhibitors.

Mutations in the BRAF (B-raf serine-threonine-protein kinase) gene occur in the majority of melanoma patients and significantly contribute to the progression of the disease. One of the most commonly used methods for treating melanoma is the use of BRAF and MEK (mitogen-activated protein kinase kinase) inhibitors. Unfor...

M. Kot, A. Simiczyjew, Katarzyna Pietraszek-Gremplewicz et al. · Biochimica et biophysica act... · 0 citations