Dou-Sheng Zhang

Prediction of Ocular Toxicity of Prostaglandin F2α Analogs Based on Local Computational Models: Superiority over Global Models and Experimental Validation

Drug-induced ocular toxicity is difficult to predict and evaluate, particularly for prostaglandin F2α (PGF2α) analogs used in the management of glaucoma. Traditional global predictive models, which are built with large and various datasets (n = 6187), provide systematic false-negative results for groups of structurally...