A Small Molecule Dual Inhibitor of agr Quorum Sensing and ATP Synthase Blocks Acute and Chronic Virulence Phenotypes in Staphylococcus aureus
The accessory gene regulator (agr) quorum-sensing system in Staphylococcus aureus plays a prominent role in acute infections caused by this common pathogen. In contrast, ATP synthase affects the ability of S. aureus to establish chronic infections and persist as small colony variants. In this study, we report that a...