Open access
Aug 2026
α-Synuclein aggregates in corticostriatal terminals impair glutamatergic transmission in the absence of neurodegeneration
Formation of presynaptic α-synuclein aggregates impairs corticostriatal function without degeneration of cortical neurons or striatal dopamine terminals, suggesting pathologic α-synuclein is sufficient for synaptic loss.
Charlotte F. Brzozowski, Zoe Fokakis, Marissa A. Menard et al.
· bioRxiv · 0 citations