Author

Douglas Natoce

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Open access Jul 2026

Paneth cell dysfunction regulates host response to SARS-CoV-2 infection 2260975

The role of the intestinal epithelium in host susceptibility and responses to SARS-CoV-2 and the influence of Paneth cells on the outcome of SARS-CoV-2 infection are addressed and highlight the importance of gastrointestinal health in shaping innate immune cells in the airways and host response to respiratory viruses.

Marisa R. Joldrichsen, Douglas Natoce, R. Woodfint et al. · Journal of Immunology · 0 citations

Open access Jul 2026

Neutrophil Elastase Regulates both Innate and Adaptive Immunity in SARS-CoV-2-Infected Mice 2260457

Findings identify NE as a critical regulator of host immunity and viral replication during SARS-CoV-2 infection and the role played by ELANE in antiviral immunity and disease severity is defined.

Douglas Natoce, Sungjun Yoo, R. Woodfint et al. · Journal of Immunology · 0 citations

Jul 2026

Investigation of the role of the cystic fibrosis transmembrane conductance regulator (CFTR) in SARS-CoV-2 pathogenesis 2308341

The data show that the severity of SARS-CoV-2 infection in different mice CFTR genotypes is highly dependent on the age and gender.

M. Wahba, P. Boyaka, E. Cormet-Boyaka et al. · Journal of Immunology · 0 citations

Open access Jul 2026

The Intestinal Microbiome Differentially Modulates SARS-CoV-2-Induced Pathology and Host Immune Response in Male and Female Mice 2261020

It is suggested that commensal microbes-dependent and -independent mechanisms contribute to the difference of outcome after SARS-CoV-2 infection of males and females.

R. Woodfint, Douglas Natoce, Sungjun Yoo et al. · Journal of Immunology · 0 citations