abCRISPR: deep learning-based design of abasic gRNA sequences for specific CRISPR-Cas9 genome editing
Abstract Summary CRISPR-Cas9 has become a widely used tool for genome editing. However, its off-target cleavage caused by partial sequence matches with guide RNAs (gRNAs) remains a critical limitation. Recently, abasic gRNAs (ØXØ) have been developed to enhance target specificity, but their effects vary depending on th...