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Dražen Petrov

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Open access Jul 2026

Unveiling the KRAS Relationship between Affinity and Dynamics: A Molecular Simulations Study

Kirsten rat sarcoma virus protein (KRAS) is one of the most important targets in current drug discovery. Its intrinsic properties, including a high structural flexibility and a shallow polar pocket, make KRAS extremely difficult to target. In fact, for a long time it was considered undruggable. A better understanding o...

Nadine Grundschober, Viktorija Dujmovic, C. Oostenbrink et al. · 0 citations

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