Human pluripotent stem cell-derived dopaminergic neurons have become central platforms for Parkinson’s disease (PD) modeling and regenerative medicine. Current differentiation systems can efficiently generate TH+/FOXA2+/LMX1A+ ventral midbrain-like populations. Although canonical markers remain important components of...
Duc-Hiep Bach, T. Nguyen· Cell Communication and Signa...· 0 citations
The approval of lifileucel in 2024 marked an important milestone in oncology as the first cellular therapy authorized for a solid tumor and a review of the biological obstacles, emerging convergence strategies, and translational frameworks including biomarker-guided patient selection that define this new area.
Duc-Hiep Bach, Van T. Hoang, T. Pham et al.· Cancer Cell International· 2 citations
A three-layer mechanistic framework is presented that reframes manufacturing as biology: integration biology determines genomic risk and transgene stability; clonal fitness shapes persistence, dominance, and exhaustion; and epigenomic imprinting preconfigures functional trajectories.
Duc-Hiep Bach, T. Nguyen· Human Gene Therapy· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.