Sep 2026
A pyridone-fused imidazo[1,2-a]pyridine hybrid binds to tubulin at the vinblastine site, depolymerizes microtubules and inhibits Cancer cell proliferation.
Tubulin remains a key target in anticancer therapy, motivating the development of structurally novel small-molecule inhibitors. The vinblastine-binding site on tubulin is a well-established and druggable pocket that accommodates structurally diverse ligands, including small-molecule inhibitors. Imidazo[1,2-a]pyridine r...
Mehak Sood, Tuhin Sarkar, Kanchan Chaurasiya et al.
· Bioorganic chemistry (Print) · 0 citations