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Author

Duo-Meng Yang

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Open access Aug 2026

Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1

The non-canonical caspase-4 inflammasome is a crucial anti-bacterial immune mechanism, yet, when dysregulated, may contribute to sepsis pathogenesis. Its regulation is heavily reliant on transcriptional control of caspase-4 expression. However, posttranslational regulation of the caspase-4 inflammasome remains poorly u...

Duo-Meng Yang, Jason G. Cahoon, T. Geng et al. · 0 citations
Jul 2026

MEX3B as a Potent Regulator of Inflammasome Signaling 2267250

Deletion of MEX3B inhibited caspase-4 and gasdermin D activation, pyroptosis, and secretion of inflammasome-dependent inflammatory cytokines in human cell lines and murine primary macrophages and suggested that MEX3B is a pan-inflammasome regulator targeting inflammatory caspases.

Peng-Hua Wang, Jason G. Cahoon, Duo-Meng Yang et al. · 0 citations

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