Isomeric Indole-Chalcone Surrogates as Complementary Reporters of Nucleic Acid Binding Interactions.
We report isomeric indole-6-hydroxyindanone (Ind6HI) nucleobase surrogates as complementary environment-sensitive fluorescent reporters for probing nucleic acid (NA) binding interactions directly within the native helix. Both probes act as base-stacked surrogates to occupy similar microenvironments within the helix. Ho...