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Open access Aug 2026

Associations Between Cerebral Amyloid Angiopathy, Cognitive Impairment, and Depressive Symptoms

Background and Objectives Cerebral amyloid angiopathy (CAA) is associated with intracerebral hemorrhage, cognitive decline, and dementia. We examined (1) associations between CAA, cognitive impairment, and depressive symptoms; (2) whether depressive symptoms mediate the relationship between CAA and cognition; and (3) w...

Nikita Nukala, Ryan T. Muir, Andrew E. Beaudin et al. · 0 citations
Open access Sep 2026

Can Cognitive Reserve Moderate the Association Between Brain Structure and Later-Life Behavioural Symptoms?

IntroductionCognitive reserve (CR) buffers against cognitive manifestations of neurodegenerative disease; little is known about CR and neuropsychiatric symptoms (NPS). We investigated CR moderation on the relationship between AD-related cortical changes and NPS.MethodsCross-sectional data from 455 participants in COMPA...

G. Sidhu, Dylan X. Guan, M. Ghahremani et al. · 0 citations
Open access Sep 2026

Cognitive reserve and everyday functioning in cognitively unimpaired older adults: evidence from the CAN-PROTECT study.

BACKGROUND Cognitive reserve (CR) is thought to buffer against the clinical manifestation of dementia, preserving cognitive function despite accumulating pathology. However, less is known about how CR relates to the capacity to independently perform activities of daily living (ADL), particularly among cognitively unimp...

M. Ghahremani, Dylan X. Guan, C. Ballard et al. · 0 citations

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