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Author

E. A. Kane

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Open access Aug 2026

ATF4 activates a transcriptional program that chronically suppresses mTOR activity and promotes neurodegeneration in Parkinson disease models.

This work finds a critical pathway by which chronic ISR activation promotes neurodegeneration in neurotoxin and α synucleinopathy models of PD in vitro and in vivo and defines a maladaptive ISR/ATF4-mTOR pathway with potential therapeutic relevance for neurodegenerative disorders characterized by chronic ISR activation...

Matthew D. Demmings, E. A. Kane, E. Tennyson et al. · 0 citations

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