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Quantitative sleep spindle analysis may represent a scalable, non-invasive neurophysiological biomarker with potential applications in early identification, mechanistic research, and outcome monitoring in ASD.
Findings provide exploratory evidence of longitudinal volumetric change in a teriflunomide-treated POMS cohort despite residual clinical disease activity, and should be interpreted cautiously and warrant confirmation in larger, controlled longitudinal studies.
High-dose oral prednisolone and ACTH therapies demonstrated comparable efficacy in reducing electrographic and clinical seizure burden in children with IESS and improvement in epileptiform activity, as reflected by reductions in the BASED score is strongly associated with better clinical outcomes.
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