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Review Open access Sep 2026

Pathophysiological role of platelet-derived growth factors in chronic liver disease.

Platelet-derived growth factor (PDGF) and its receptor (PDGFR) signaling serves as a central driver of hepatic stellate cell (HSC) activation and extracellular matrix deposition in chronic liver diseases. Upon ligand binding, PDGFR undergoes dimerization and autophosphorylation, initiating key intracellular signaling p...

Eun-A Ko, Sung-Cherl Jung, E. Baek · 0 citations

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