Elevated type I interferon levels during Influenza virus infection profoundly suppress pulmonary innate and adaptive immunity and exacerbate disease 2257518
Most mouse studies aimed at investigating the roles of specific cytokines in disease states use mice deficient for the cytokine or its receptor, or antibody treatment to block its signaling. While such analyses have found relatively minor impacts for type I interferon (IFN-I) signals during Influenza A (IAV) infe...