Genomic DNA is packaged into chromatin through a fundamental repeating unit known as the nucleosome core particle. Chromatinized genomic DNA is constantly exposed to endogenous and exogenous stresses that result in DNA damage, which must be repaired to maintain genome stability. Single-strand breaks (SSBs) are a preval...
Daniel J. Boesch, Nadia I. Martin, Chantal A. Kontor et al.· Nature Communications· 0 citations
Nucleopeptide-based hydrogels are attracting growing interest owing to their biocompatibility and wide range of applications, particularly in biotechnology. Their enhanced versatility compared to purely peptide-based systems enables fine-tuning of macroscopic properties to meet specific requirements. However, rationa...
Corentin Boulogne, J'er'emy Morere, Noée Sigalas et al.· Journal of Physical Chemistr...· 0 citations
We report a comprehensive study of the photoinduced isomerization-cyclization cascade of o-amino(hetero)arylidenethiazolidine-2,4-diones (Het)Ar-TZDs 1, combining computational, synthetic, and kinetic investigations. Time-dependent density functional theory (TD-DFT) calculations were used to predict absorption maxima a...
Vincent Bruneau, Johanne Coutard, Nina Bukhtiiarova et al.· Chemistry· 0 citations
It is demonstrated that pharmacological inhibition of the glyoxalase system—the major pathway for MGO detoxification—restores drug sensitivity in patient-derived cells and xenograft models, revealing a context-dependent metabolic vulnerability in AKR1A1 loss conditions.
