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Open access Sep 2026

Cell-cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors

The relationship between cell cycle length and differentiation competence has been studied in developmental biology, particularly in embryonic stem cells, which show a very short G1 phase required to maintain pluripotency. How and whether this principle operates in cancer— where the cell cycle is deregulated and G1 is...

K. Hayatigolkhatmi, R. Valzelli, E. Ceccacci et al. · 0 citations
Open access Sep 2026

TANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning

Coordinated RNA and protein synthesis is fundamental to cell function and survival. Here, we show that TANGO6, a nucleocytoplasmic RNA binding protein, is an integral component of the proteostasis control axis, regulating both transcription and translation. In the nucleus, TANGO6 is recruited to gene promoters alongsid...

Gonzalo Bigliani, C. Ballaré, José Wojnacki et al. · 0 citations

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