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Author

E. Borazanci

2 papers indexed here

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Review Sep 2026

Abstract A132: A Phase 2 Study to Investigate the Efficacy and Safety of Acoustic Cluster Therapy with Modified FOLFIRINOX in Patients with Locally Advanced and Borderline Resectable Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) remains difficult to treat due to its dense stromal microenvironment, which limits drug penetration and chemotherapy efficacy. Acoustic Cluster Therapy (ACT) is an investigational ultrasound-mediated drug delivery platform designed to enhance intratumoral delivery of system...

Erin Pierce, Ragnar Bendiksen, Amir Snapir et al. · 0 citations
Sep 2026

Abstract B072: Resistance to the RAS inhibitor daraxonrasib due to the LZTR1 mutation in a KRAS G12D mutated pancreatic ductal adenocarcinoma patient-derived organoid model

Targeted therapy with RAS (Rat sarcoma) inhibitors are increasingly used in the treatment of pancreatic ductal adenocarcinoma (PDAC) given the prevalence of KRAS (Kirsten rat sarcoma virus) mutations in over 90% and poor prognosis with 13.7% five-year survival in this population despite standard treatment.1,2 Leu...

Alexa F. Viniotis, Jaeger Moore, R. Soldi et al. · 0 citations

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