Open access
Sep 2026
Metabolic sensor AMPK licenses intestinal CD103+ DCs to induce Treg responses
Intestinal dendritic cells (DCs) play a central role in maintaining gut tolerance through priming of peripheral regulatory T cells (pTreg cells). DC tolerogenicity has been linked to catabolic metabolism, but the role of AMP-activated kinase (AMPK), a key regulator of catabolic metabolism, in regulating intestinal tole...
T. Patente, Julian van Duijvenvoorde, Graham A. Heieis et al.
· Science Advances · 0 citations